PU.1 Shapes Host Epigenetic Responses to Mycobacterium tuberculosis and Represents a Target for Host Directed Therapy
Jérémie Poschmann, Jie Liu, Caio César Barbosa Bomfim, Alice Mollé, Wenjie Sun, Taylor W. Foreman, Colette Cruesy, Gosset Pierre, Deepak Kaushal, Gennaro De Libero, Céline Cougoule, Shyam Prabhakar, Amit Singhal
This study identifies PU.1 as a key transcription factor regulating epigenetic responses to Mtb, showing its role in supporting infection and potential as a therapeutic target.
bioRxiv · Sep 9, 2025 · PreprintImmunology