Céline Cougoule

Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies

This study uses dual human lung models to evaluate anti-tuberculosis drugs and host-directed therapies, revealing compartment-specific efficacy and immune responses.

A TAK1-Driven NLRP1 Inflammasome Pathway Revealed by Phosphatase-Targeting Environmental Toxins

The paper identifies PP1 and PP2A phosphatases as regulators of NLRP1 inflammasome activation, showing that environmental toxins and viral infections trigger this pathway via TAK1 and p38 kinases.

Verapamil limits inflammation by restoring VGCC-driven epithelial Ca2+ in models of cystic fibrosis

This study shows verapamil reduces inflammation in cystic fibrosis by normalizing epithelial calcium signaling and oxidative stress in zebrafish and human cells.

PU.1 Shapes Host Epigenetic Responses to Mycobacterium tuberculosis and Represents a Target for Host Directed Therapy

This study identifies PU.1 as a key transcription factor regulating epigenetic responses to Mtb, showing its role in supporting infection and potential as a therapeutic target.

Curcumin-mediated NRF2 induction limits inflammatory damage in preclinical models of cystic fibrosis

This study shows curcumin improves inflammation and tissue damage in cystic fibrosis by restoring NRF2 activity in zebrafish and patient-derived airway organoids.

Mycobacteria-host interactions in human bronchiolar airway organoids

This study uses human airway organoids to model tuberculosis infection, showing mycobacteria infect epithelial cells with low efficiency and the organoid microenvironment controls but does not eliminate the pathogen.