Wenjie Sun

Repetitive transcranial magnetic stimulation targeting motor cortical region induces cell-type-specific transcriptional reprogramming and behavioral recovery in non-human primate model of Rett syndrome

This study shows that rTMS targeting the motor cortex in a non-human primate model of Rett syndrome improves behavioral outcomes and induces cell-type-specific transcriptional changes.

CoCUT&Tag maps linked chromatin states at single-molecule, single-cell resolution

The paper introduces CoCUT&Tag, a method to measure co-occupancy of two chromatin features at single-cell resolution, and shows that bivalent chromatin enhances gene activation during hematopoietic differentiation.

Elimination of intramuscular immunoglobulin accumulation alleviates Duchenne Muscular Dystrophy

This study identifies IgG accumulation in dystrophin-deficient muscle as a driver of DMD progression and shows that B cell depletion reduces it, offering a potential therapeutic strategy.

Evolutionarily Conserved T-tubule-Mitochondria Contacts in Striated Muscle

This study identifies evolutionarily conserved T-tubule-Mitochondria contacts in skeletal and cardiac muscles using zebrafish and mice, revealing their role in muscle physiology and disease.

PU.1 Shapes Host Epigenetic Responses to Mycobacterium tuberculosis and Represents a Target for Host Directed Therapy

This study identifies PU.1 as a key transcription factor regulating epigenetic responses to Mtb, showing its role in supporting infection and potential as a therapeutic target.

DUBStepR: correlation-based feature selection for clustering single-cell RNA sequencing data

DUBStepR improves single-cell clustering by selecting features using gene-gene correlations and a Density Index, outperforming existing methods and detecting rare cell populations.

scConsensus: combining supervised and unsupervised clustering for cell type identification in single-cell RNA sequencing data

scConsensus combines supervised and unsupervised clustering to improve cell type identification in single-cell RNA sequencing data by integrating results and refining clusters with differentially expressed genes.

Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

The paper identifies a convergent molecular subtype in ASD by integrating epigenomic and transcriptomic data, revealing shared dysregulation and links to immune processes and genetic risk variants.

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.

Correlated Gene Modules Uncovered by Single-Cell Transcriptomics with High Detectability and Accuracy

The paper identifies correlated gene modules using single-cell RNA-seq, revealing biological functions and regulatory relationships through covariance analysis.

Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic forms of autism in postmortem human brain tissue.