Author

Constanze Schneider

Primary ORCID profile (0009-0005-0092-5999 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Constanze SchneideriD3 papers · Broad Institute

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Andrea NistiD· 1 shared Andreas von Deimling· 1 shared Daniel SpeideliD· 1 shared Florian Rothweiler· 1 shared Jindrich CinatliD· 1 shared Marco Mernberger· 1 shared Martin MichaelisiD· 1 shared Tamara Rothenburger· 1 shared

Activity by Year

2018-2018 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperPharmacology & Toxicology

Andrea NistORCID

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1 paper

Recent·Most cited

TP53 mutations and drug sensitivity in acute myeloid leukaemia cells with acquired MDM2 inhibitor resistance

Martin Michaelis, Constanze Schneider, Florian Rothweiler, Tamara Rothenburger, Marco Mernberger, Andrea Nist, Andreas von Deimling, Daniel Speidel, Thorsten Stiewe, Jindrich Cinatl

This study establishes MDM2 inhibitor-resistant AML sub-lines and finds that resistance arises from pre-existing TP53 mutations or de novo mutations, with variable drug sensitivity despite loss of p53 function.

bioRxiv · Aug 30, 2018 · PreprintPharmacology & Toxicology