Andrea Nist

Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation

The paper identifies hangover's role in regulating gene expression by inhibiting NSL-mediated H4K16 acetylation at transcriptional start sites in Drosophila.

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

This study identifies synergistic metabolic inhibitors that selectively target ovarian and colorectal cancer cells by disrupting both glycolysis and oxidative phosphorylation.

SAMD1 suppresses epithelial-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma

This study identifies SAMD1 as a repressor of EMT-related genes in PDAC, showing that its loss increases migration and that FBXO11 ubiquitinates SAMD1 to inhibit its function.

IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells

This study shows IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent excessive inflammation in AML cells, revealing a potential therapeutic target.

The H2A.Z.1/PWWP2A/NuRD-associated protein HMG20A controls early head and heart developmental transcription programs

This study identifies HMG20A as a key regulator of head and heart development by modulating transcription programs in neural crest cells and cardiomyocytes through its association with the H2A.Z/PWWP2A/NuRD complex.

RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling

The paper shows RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling by competing with nucleosome substrates, suggesting an evolutionary conserved mechanism.

Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis

This study identifies Ush's role in regulating gene expression, metabolism, and cell cycle in Drosophila hematopoiesis through its interaction with the NuRD complex.

TP53 mutations and drug sensitivity in acute myeloid leukaemia cells with acquired MDM2 inhibitor resistance

This study establishes MDM2 inhibitor-resistant AML sub-lines and finds that resistance arises from pre-existing TP53 mutations or de novo mutations, with variable drug sensitivity despite loss of p53 function.