Jindrich Cinatl

The COVID-19 PHARMACOME: A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization

The paper presents a drug-target-mechanism graph to identify synergistic drug combinations for SARS-CoV-2 treatment, validated through experimental testing.

Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication

This study identifies growth factor receptor signaling as a key pathway for SARS-CoV-2 replication and shows that inhibiting it prevents viral replication in human cells.

Elevated expression of LGR5 and WNT signalling factors in neuroblastoma cells with acquired drug resistance

This study shows that LGR5 and WNT signaling factors are elevated in neuroblastoma cell lines with acquired drug resistance, suggesting a role for the WNT pathway in resistance mechanisms.

TP53 mutations and drug sensitivity in acute myeloid leukaemia cells with acquired MDM2 inhibitor resistance

This study establishes MDM2 inhibitor-resistant AML sub-lines and finds that resistance arises from pre-existing TP53 mutations or de novo mutations, with variable drug sensitivity despite loss of p53 function.