Martin Michaelis

This study characterizes phenotypic plasticity in EGFR inhibitor-resistant NSCLC cell lines, showing diverse resistance mechanisms and metabolic adaptations across sublines.

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

This study shows that LGR5 and WNT signaling factors are elevated in neuroblastoma cell lines with acquired drug resistance, suggesting a role for the WNT pathway in resistance mechanisms.

This study establishes MDM2 inhibitor-resistant AML sub-lines and finds that resistance arises from pre-existing TP53 mutations or de novo mutations, with variable drug sensitivity despite loss of p53 function.

The paper identifies 22 likely transporter proteins in a minimal bacterial genome, highlighting their role in nutrient uptake and waste disposal despite many metabolic enzymes being removed.