Loss of neuronal lysosomal acid lipase drives amyloid pathology in Alzheimer's disease
Alexandra Barnett, Elizabeth M. McNair, Lamar Dawkins, Jian Zou, Viktoriya D. Nikolova, Sheryl S. Moy, Greg Trevor Sutherland, Julia Stevens, Meagan Colie, Kemi Katemboh, Hope Kellner, Katherine Ho, Corina Damian, Sagan DeCastro, Ryan P. Vetreno, Leon G. Coleman
This study identifies neuronal lysosomal acid lipase (LAL) loss as a driver of amyloid pathology in Alzheimer's disease by linking disrupted lipophagy to Aβ accumulation and cognitive deficits.
Alzheimer s & Dementia · Jul 1, 2025Peer-reviewedNeuroscience