Ryan P. Vetreno

This study shows that chronic intermittent ethanol exposure in female mice leads to increased ethanol tolerance and persistent memory and anxiety-like behavioral changes during abstinence.

This study identifies a distinct reactive microglial phenotype in human AUD that activates astrocytes, contributing to neurodegeneration and heavy drinking.

This study identifies neuronal lysosomal acid lipase (LAL) loss as a driver of amyloid pathology in Alzheimer's disease by linking disrupted lipophagy to Aβ accumulation and cognitive deficits.

This study shows adolescent binge ethanol exposure leads to lasting alcohol tolerance in adulthood, mediated by proinflammatory HMGB1 signaling, and that blocking HMGB1 reverses this tolerance.

This study evaluates the effects of SBI-553, a β-arrestin-biased allosteric modulator of NTSR1, on ethanol-related behaviors in rodents, finding reduced ethanol consumption and altered sensitivity to ethanol effects.

This study shows that TLR3 agonism increases alcohol consumption in rats, with females being more sensitive to lower doses than males.

This study shows that TLR7 activation with imiquimod increases ethanol self-administration and induces TLR-related gene expression in rats, with sex-specific effects on drinking behavior and molecular responses.

This study examines how adolescent intermittent ethanol exposure affects interneurons and perineuronal nets in the adult prefrontal cortex and striatum, finding increased perineuronal nets without changes in interneuron numbers.