Sex differences in vaccine-induced neuraminidase cross-recognition impact H5N1 dissemination to the lower respiratory tract in mice
Sabal Chaulagain, Anne P. Werner, Maclaine A. Parish, Sattya Narayan Talukdar, Anna Yin, Brittany Seibert, Tianle Zhang, Jennifer A. Liu, Cosette Schneider, Lynda Coughlan, Andrew S Pekosz, Sabra L. Klein
This study shows that sex differences in vaccine-induced neuraminidase (NA) antibody responses affect H5N1 virus dissemination in mice, with females showing better protection against lower respiratory tract infection.
Vaccine · Sep 27, 2026Peer-reviewedImmunology