Lynda Coughlan

This study shows that sex differences in vaccine-induced neuraminidase (NA) antibody responses affect H5N1 virus dissemination in mice, with females showing better protection against lower respiratory tract infection.

This study shows H5N1 influenza virus can be transmitted vertically through placental and mammary routes in pregnant mice, causing developmental impairments in offspring.

This study evaluates a novel TLR4 adjuvant, BECC470s, in enhancing rHA vaccination against H5N1 influenza in mice, showing improved antibody responses but limited cross-neutralizing activity.

The paper measures antibody responses to bovine A/H5N1 HA and NA in vaccinated and infected individuals, finding that A/H1N1 infection boosts neutralizing antibodies but vaccination and A/H3N2 infection do not.

This study evaluates BECC adjuvants' ability to enhance HA-based influenza vaccine efficacy in mice, showing improved immune responses and viral clearance.

The paper determines the structure of the ChAdOx1 adenovirus vector and identifies interactions with CAR and PF4, proposing a mechanism for vaccine-induced immune thrombotic thrombocytopenia.