R-Ras coordinates reciprocal activation of ERK5 and ERK1/2 under single pathway inhibition in melanoma
Ignazia Tusa, Cosimo Mazzei, Dimitri Papini, Alessio Menconi, Ylenia Sfragano, Alessandro Tubita, Giulia Montemurro, Julia Penitenti, Azucena Esparı́s-Ogando, Atanasio Pandiella, Elisabetta Rovida
This study shows that R-Ras coordinates reciprocal activation of ERK5 and ERK1/2 pathways in melanoma under MAPK inhibition, suggesting co-targeting R-Ras and MAPK signaling could improve therapy.
bioRxiv · Jul 20, 2026 · PreprintCancer Biology