Cancer BiologybioRxivPreprint
R-Ras coordinates reciprocal activation of ERK5 and ERK1/2 under single pathway inhibition in melanoma
Ignazia Tusa, Cosimo Mazzei, Dimitri Papini…·Elisabetta Rovida
This study shows that R-Ras coordinates reciprocal activation of ERK5 and ERK1/2 pathways in melanoma under MAPK inhibition, suggesting co-targeting R-Ras and MAPK signaling could improve therapy.
DOI 10.64898/2026.07.17.737152