Atanasio Pandiella

R-Ras coordinates reciprocal activation of ERK5 and ERK1/2 under single pathway inhibition in melanoma

This study shows that R-Ras coordinates reciprocal activation of ERK5 and ERK1/2 pathways in melanoma under MAPK inhibition, suggesting co-targeting R-Ras and MAPK signaling could improve therapy.

Computational mapping of antibody-receptor energy landscapes to predict membrane internalization

This study uses molecular dynamics simulations to predict antibody internalization by mapping energy landscapes between antibodies and JAM-A receptors, identifying key interactions that drive endocytosis.

VCAN is essential for ERK5-driven tumorigenesis in soft tissue sarcoma

This study identifies VCAN as a novel transcriptional target of ERK5 and shows its essential role in ERK5-driven tumorigenesis in soft tissue sarcoma.