Genome-wide mutational signatures of immunological diversification in normal lymphocytes
Heather E. Machado, Emily Mitchell, Nina Friesgaard Øbro, Kirsten Kübler, Megan Davies, Francesco Maura, Daniel A. Leongamornlert, Mathijs Arnoud Sanders, Alex Cagan, Craig McDonald, Miriam Belmonte, Mairi S. Shepherd, Robert J. Osborne, Krishnaa T. A. Mahbubani, Iñigo Martincorena, , Peter J. Campbell
The paper analyzes the mutational landscape of normal lymphocytes, revealing off-target effects of programmed genome engineering and the impact of differentiation and microenvironment exposure.
bioRxiv · Apr 29, 2021 · PreprintGenomics