Author
Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0001-6225-2033Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Viacheslav A. Kriachkov, Jeralyn Ching Wen Hui, James Lancaster…·Hamish W. King
The paper uses single-cell CRISPR activation screens in human B cells to link non-coding autoimmune risk loci to their cis-regulatory target genes, revealing shared genetic mechanisms across diseases.
Giorgia Chiodin, Dylan J. Tatterton, Philip J. Rock…·Francesco Forconi
This study shows that DC-SIGN binding to sIg-Mann on follicular lymphoma cells promotes adhesion to VCAM-1 and survival, suggesting a therapeutic target for FL.
Fiamma Salerno, Alex J. Whale, Louise S. Matheson…·Martin Turner
This study identifies ZFP36L1 and ZFP36L2 as RNA-binding proteins that regulate the G2-M checkpoint in GC B cells to prevent replication stress and maintain genome stability.
Panagiota Vardaka, Ben Kemp, Sophie Stephenson…·Reuben M. Tooze
This study shows that enforced MYC expression alters transcriptional programs and metabolic shifts during human plasma cell differentiation without causing transformation.
Emily Mitchell, My H. Pham, Anna Clay…·Michael R. Stratton
This study examines the long-term effects of chemotherapy on normal blood cells by analyzing mutation burdens and cell population structure in treated individuals.
Heather E. Machado, Emily Mitchell, Nina Friesgaard Øbro…·Peter J. Campbell
The paper analyzes the mutational landscape of normal lymphocytes, revealing off-target effects of programmed genome engineering and the impact of differentiation and microenvironment exposure.