Clonal dynamics of haematopoiesis across the human lifespan
Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J. Dawson, Nicole Mende, Emily F. Calderbank, Hyunchul Jung, Thomas J. Mitchell, Tim H. H. Coorens, David H. Spencer, Heather E. Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A. Fabre, , Peter J. Campbell
This study tracks clonal dynamics in human haematopoiesis across age, finding that clonal diversity sharply declines after 70, driven by positive selection on many genes and loss of Y chromosome in males.
Nature · Jun 1, 2022Peer-reviewedGenomics