BiochemistrybioRxiv
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
Lin Guo, Jacob R. Mann, Jocelyn C. Mauna…·James Shorter
The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.
DOI 10.1016/j.molcel.2025.12.009