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Cristine Charlesworth

Mayo Clinic

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Biochemistry· 1

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

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Adam NguyeniD· 1 shared Alexander MevesiD· 1 shared Benjamin J. MaddeniD· 1 shared Caleigh M. AzumayaiD· 1 shared Gabriele CordaraiD· 1 shared Hedda JohanneseniD· 1 shared Joel Benjamin HeimiD· 1 shared Matthew C. ChaniD· 1 shared

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Adam NguyenORCID

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1 paper

Recent·Most cited

BiochemistryStructurePeer-reviewedOct 1, 2026

Shared ligand-blocking mechanism but distinct conformational modulation by α5-targeting antibodies BIIG2 and MINT1526A

Adam Nguyen, Joel Benjamin Heim, Gabriele Cordara…·Melody G. Campbell

This study compares two anti-α5β1 antibodies, showing they share ligand-blocking mechanisms but differ in conformational modulation, with implications for therapeutic design.

DOI 10.1016/j.str.2026.08.001

humanexperimental assay

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