Matthew C. Chan

Shared ligand-blocking mechanism but distinct conformational modulation by α5-targeting antibodies BIIG2 and MINT1526A

This study compares two anti-α5β1 antibodies, showing they share ligand-blocking mechanisms but differ in conformational modulation, with implications for therapeutic design.

A codon-sensitive conformational switch gates commitment to translation start sites

The paper identifies a conformational switch in eIF5 that regulates translation initiation at AUG and non-AUG codons by stabilizing or destabilizing the initiation complex.

Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins

The paper investigates the evolutionary origin and structural role of the I domain in integrin proteins, showing it mimics ligands to enable activation and expand cellular communication.

SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals

This study shows SARS-CoV-2 nsp1 inhibits translation in bat cells and human cells, revealing its broad activity across mammals.

TLmutation: predicting the effects of mutations using transfer learning

TLmutation uses transfer learning to predict mutation effects by transferring knowledge between protein functions and homologous proteins, improving predictions from limited data.