Melody G. Campbell

This study compares two anti-α5β1 antibodies, showing they share ligand-blocking mechanisms but differ in conformational modulation, with implications for therapeutic design.

The paper identifies previously unknown Scm3/HJURP orthologs in metazoans using remote homology, structural modeling, and functional genetics, revealing their conserved role in centromere function despite sequence divergence.

The paper identifies a conformational switch in eIF5 that regulates translation initiation at AUG and non-AUG codons by stabilizing or destabilizing the initiation complex.

The paper investigates the evolutionary origin and structural role of the I domain in integrin proteins, showing it mimics ligands to enable activation and expand cellular communication.

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

This study shows SARS-CoV-2 nsp1 inhibits translation in bat cells and human cells, revealing its broad activity across mammals.