Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple AD ligands
Jessica A. Greven, Joshua R. Wydra, Rory A. Greer, Cynthia Zhi, David A. Price, Jordyn D. Svoboda, Christopher Camitta, Mya Washington, Daisy W. Leung, Yuhua Song, Jennifer M Alexander‐Brett, Tom J. Brett
This study maps TREM2-ligand interactions using biolayer interferometry, revealing shared binding surfaces for apoE4, oAb42, and TDP-43, and a unique site for IL-34.
Molecular Neurodegeneration · Jan 9, 2025Peer-reviewedBiophysics