Author

Tom J. Brett

Washington University in St. LouisORCID 0000-0002-6871-6676Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:GWAS / association mapping· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Jennifer M Alexander‐BrettiD· 2 shared Jessica A. Greven· 2 shared Alberto LleóiD· 1 shared Alzheimer’s Disease Neuroimaging Initiative· 1 shared Amanda HeslegraveiD· 1 shared Bengt NellgårdiD· 1 shared Bruno Benitez· 1 shared Carlos CruchagaiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

Jennifer M Alexander‐BrettORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple AD ligands

Jessica A. Greven, Joshua R. Wydra, Rory A. Greer, Cynthia Zhi, David A. Price, Jordyn D. Svoboda, Christopher Camitta, Mya Washington, Daisy W. Leung, Yuhua Song, Jennifer M Alexander‐Brett, Tom J. Brett

This study maps TREM2-ligand interactions using biolayer interferometry, revealing shared binding surfaces for apoE4, oAb42, and TDP-43, and a unique site for IL-34.

Molecular Neurodegeneration · Jan 9, 2025Peer-reviewedBiophysics

Structural and functional analysis of TREM2 interactions with amyloid beta reveal molecular mechanisms that mediate phagocytosis of oligomeric amyloid beta

Jessica A. Greven, Omar Osario, Jay C. Nix, Jennifer M Alexander‐Brett, Tom J. Brett

bioRxiv · May 23, 2024 · PreprintBiophysics

The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk

Yuetiva K. Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert J. Mikesell, Zeran Li, Jorge L. Del‐Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph L. Bradley, Bruno Benitez, John Budde, Laura Ibañez, Maria Victoria Fernandez, , Carlos Cruchaga

This study identifies genetic variants in the MS4A gene cluster associated with higher sTREM2 levels and reduced Alzheimer disease risk, suggesting MS4A4A regulates sTREM2 and contributes to AD pathogenesis.

Science Translational Medicine · Aug 14, 2019Peer-reviewedGenomics