Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts
K. E. C. Blokland, M. Nizamoglu, H. Habibie, T. Borghuis, M. Schuliga, B. N. Melgert, D. A. Knight, C.-A. Brandsma, S. D. Pouwels, J. K. Burgess
This study shows that fibrotic stiffness activates fibrotic genes and senescence-associated secretory factors in lung fibroblasts, potentially driving disease progression in IPF.
bioRxiv · Sep 27, 2022Cell Biology