Author

C.-A. Brandsma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

W. Timens· 5 shared M. van den Berge· 4 shared R. R. Woldhuis· 3 shared B. N. Melgert· 2 shared H. Habibie· 2 shared W. Kooistra· 2 shared A. Cvejic· 1 shared A. J. van Oosterhout· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersCell Biology

W. Timens

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Role of RANKL in Alveolar Epithelial Cell Regeneration: Potential Novel Contributor to Lung Tissue Repair

H. Habibie, S. Song, C. E. Boorsma, K. S. S. Putri, C. Reker-Smit, J. Vlasma, M. J. R. Ruigrok, R. H. Cool, X. Wu, Y. Wang, W. Quax, P. Olinga, C.-A. Brandsma, W. Timens, J. Burgess, B. N. Melgert

This study investigates RANKL's role in lung epithelial cell regeneration, finding it promotes type II alveolar epithelial cell regeneration and may contribute to lung tissue repair.

bioRxiv · Oct 11, 2023 · PreprintCell Biology

Strong paracrine effects of SASP from senescence-induced severe early-onset COPD-derived fibroblasts

R. A. Meuleman, W. Timens, W. Kooistra, M. van den Berge, C.-A. Brandsma, R. R. Woldhuis

This study shows that SASP from senescent fibroblasts in severe early-onset COPD promotes paracrine senescence, inflammation, and ECM dysregulation in surrounding fibroblasts.

bioRxiv · Sep 1, 2023 · PreprintCell Biology

E-cigarette vapour induces cellular senescence in primary lung fibroblasts and may contribute to lung pathology

J. Bozier, B. Wang, M. de Vries, C.-A. Brandsma, M. van den Berge, W. Timens, I. H. Heijink, B. G. G. Oliver, R. R. Woldhuis

This study shows E-cigarette vapour induces cellular senescence in primary human lung fibroblasts, impairing tissue repair, but not in a mouse model.

bioRxiv · Aug 30, 2023 · PreprintCell Biology

Cellular Senescence Affects ECM Regulation in COPD Lung Tissue

R. R. Woldhuis, N. J. Bekker, J. L. L. Nijnatten, M. Banchero, W. Kooistra, K. J. C. Wolters, P. L. Horvatovich, V. Guryev, M. van den Berge, W. Timens, C.-A. Brandsma

This study identifies ECM gene and protein changes in COPD lung tissue linked to cellular senescence, confirming in vivo associations previously observed in vitro.

bioRxiv · Aug 2, 2023 · PreprintPathology

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

K. E. C. Blokland, M. Nizamoglu, H. Habibie, T. Borghuis, M. Schuliga, B. N. Melgert, D. A. Knight, C.-A. Brandsma, S. D. Pouwels, J. K. Burgess

This study shows that fibrotic stiffness activates fibrotic genes and senescence-associated secretory factors in lung fibroblasts, potentially driving disease progression in IPF.

bioRxiv · Sep 27, 2022Cell Biology

A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

F. A. Vieira Braga, G. Kar, M. Berg, O. A. Carpaij, K. Polanski, L. M. Simon, S. Brouwer, T. Gomes, L. Hesse, J. Jiang, E. S. Fasouli, M. Efremova, R. Vento-Tormo, K. Affleck, S. Palit, , S. A. Teichmann

The paper uses single-cell transcriptomics to identify novel cell states in healthy and asthmatic lung tissues, revealing changes in cell communication and immune responses.

bioRxiv · Jan 23, 2019 · PreprintImmunology