Author

B. N. Melgert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 3 Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

H. Habibie· 3 shared P. Olinga· 3 shared T. Borghuis· 3 shared W. Timens· 3 shared C. E. Boorsma· 2 shared C. Reker-Smit· 2 shared C.-A. Brandsma· 2 shared J. Burgess· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

H. Habibie

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Role of RANKL in Alveolar Epithelial Cell Regeneration: Potential Novel Contributor to Lung Tissue Repair

H. Habibie, S. Song, C. E. Boorsma, K. S. S. Putri, C. Reker-Smit, J. Vlasma, M. J. R. Ruigrok, R. H. Cool, X. Wu, Y. Wang, W. Quax, P. Olinga, C.-A. Brandsma, W. Timens, J. Burgess, B. N. Melgert

This study investigates RANKL's role in lung epithelial cell regeneration, finding it promotes type II alveolar epithelial cell regeneration and may contribute to lung tissue repair.

bioRxiv · Oct 11, 2023 · PreprintCell Biology

Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts

M. Nizamoglu, F. Alleblas, T. Koster, T. Borghuis, J. M. Vonk, M. J. Thomas, E. S. White, C. Kirstin Watson, W. Timens, K. C. El Kasmi, B. N. Melgert, I. H. Heijink, J. K. Burgess

This study shows that 3D fibrotic ECM hydrogels alter fibroblast fiber organization and mechanical properties, promoting pro-fibrotic responses.

bioRxiv · Aug 9, 2023Pathology

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

K. E. C. Blokland, M. Nizamoglu, H. Habibie, T. Borghuis, M. Schuliga, B. N. Melgert, D. A. Knight, C.-A. Brandsma, S. D. Pouwels, J. K. Burgess

This study shows that fibrotic stiffness activates fibrotic genes and senescence-associated secretory factors in lung fibroblasts, potentially driving disease progression in IPF.

bioRxiv · Sep 27, 2022Cell Biology

Inhalable textile microplastic fibers impair airway epithelial growth

F. van Dijk, S. S. Song, G. van Eck, X. H. Wu, S. Bos, D. Boom, I. Kooter, D. C. J. N. Spierings, R. Wardenaar, M. Cole, A. Salvati, R. Gosens, B. N. Melgert

This study shows nylon microplastic fibers impair airway epithelial growth in organoids, likely due to leaching components, highlighting risks of indoor exposure.

bioRxiv · Jan 25, 2021 · PreprintPharmacology & Toxicology

Osteoprotegerin expression in liver is induced by IL-13 through TGF-β

A. Adhyatmika, K. S. Putri, E. Gore, K. Mangnus, C. Reker-Smit, D. Schuppan, L. Beljaars, P. Olinga, B. N. Melgert

This study shows IL-13 induces OPG in liver tissue via a TGF-β-dependent pathway involving IL13 receptors and transcription factors STAT6 and AP1.

bioRxiv · Dec 11, 2020 · PreprintPathology

Osteoprotegerin is elevated in pulmonary fibrosis and associates with IPF progression

H. Habibie, K. Putri, C. E. Boorsma, D. Brass, P. Heukels, M. Wijsenbeek-Lourens, M. Kool, M. van der Berge, T. Borghuis, C. A. Brandsma, T. Gan, P. Olinga, W. Timens, N. Kahn, M. Kreuter, , B. N. Melgert

This study shows OPG levels are elevated in fibrotic lung tissue and correlate with IPF disease progression and reduced lung function.

bioRxiv · Dec 2, 2020 · PreprintPathology