Author

D. A. Kraut

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:yeast· 1

Frequent Co-Authors

A. M. Lehman· 1 shared A. R. Mornin· 1 shared A. V. Lago· 1 shared C. A. Castaneda· 1 shared C. E. Braganca· 1 shared E. L. Mallon· 1 shared E. O. Mulvey· 1 shared E. R. Ragwan· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

A. M. Lehman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate

I. M. Valentino, J. G. Llivicota-Guaman, T. P. Dao, E. O. Mulvey, A. M. Lehman, S. K. K. Galagedera, E. L. Mallon, C. A. Castaneda, D. A. Kraut

This study shows that polyubiquitinated substrates modulate UBQLN2 phase separation in a linkage-dependent manner, affecting proteasome activity and deubiquitination.

bioRxiv · Mar 15, 2024Biochemistry

Slippery sequences stall the 26S proteasome at multiple points along the translocation pathway

E. R. Ragwan, F. M. Kisker, A. R. Mornin, K. R. Weiser, A. V. Lago, D. A. Kraut

This study investigates how glycine-rich sequences affect proteasome unfolding by positioning them relative to a folded domain, revealing that proximity to the domain reduces unfolding efficiency.

bioRxiv · Mar 14, 2024Biochemistry

Mode of Targeting to the Proteasome Determines GFP Fate

C. E. Braganca, D. A. Kraut

The paper investigates how different targeting signals affect the degradation of GFP variants by the proteasome, finding that UBL domains enable degradation of more stable substrates than Ub4 degrons.

bioRxiv · Jul 15, 2020Biochemistry