Author

D. A. MacDuff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

K. Iwai· 2 shared M. J. Wood· 2 shared T.-C. Liu· 2 shared V. L. Hartley· 2 shared A. M. Qaqish· 1 shared B. T. Studnicka· 1 shared D. Cheng· 1 shared G. Liu· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

K. Iwai

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

HOIL1 mediates MDA5 activation through ubiquitination of LGP2

D. Cheng, J. Zhu, G. Liu, M. U. Gack, D. A. MacDuff

This study shows HOIL1 ubiquitinates LGP2 to activate MDA5 and induce IFN responses, highlighting a mechanism distinct from RIG-I sensing.

bioRxiv · Apr 2, 2024 · PreprintImmunology

HOIL1 regulates group 3 innate lymphoid cell numbers in the colon and protects against systemic dissemination, colonic ulceration, and lethality from Citrobacter rodentium infection

V. L. Hartley, A. M. Qaqish, M. J. Wood, B. T. Studnicka, K. Iwai, T.-C. Liu, D. A. MacDuff

This study shows HOIL1 is critical for limiting C. rodentium infection by regulating ILC3 numbers and inflammatory responses in mice.

bioRxiv · May 22, 2023Immunology

HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine

M. J. Wood, J. N. Marshall, V. L. Hartley, T.-C. Liu, K. Iwai, T. S. Stappenbeck, D. A. MacDuff

This study shows HOIL1 deficiency in mice causes type 2 inflammation in the small intestine, characterized by increased ILC2 cells and cytokine expression, independent of IL4R signaling.

bioRxiv · Mar 9, 2022Immunology