Author

M. U. Gack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

G. Liu· 3 shared A. Ensser· 1 shared A. H. Tavares· 1 shared A. Herrmann· 1 shared A. K. O'Connell· 1 shared C. Chiang· 1 shared C.-V. Chin· 1 shared D. A. MacDuff· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

G. Liu

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3 papers

Recent·Most cited

HOIL1 mediates MDA5 activation through ubiquitination of LGP2

D. Cheng, J. Zhu, G. Liu, M. U. Gack, D. A. MacDuff

This study shows HOIL1 ubiquitinates LGP2 to activate MDA5 and induce IFN responses, highlighting a mechanism distinct from RIG-I sensing.

bioRxiv · Apr 2, 2024 · PreprintImmunology

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

D.-Y. Chen, D. Kenney, C.-V. Chin, A. H. Tavares, N. Khan, H. L. Conway, G. Liu, M. C. Choudhary, H. P. Gertje, A. K. O'Connell, D. N. Kotton, A. Herrmann, A. Ensser, J. H. Connor, M. Bosmann, , M. Saeed

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

bioRxiv · Oct 13, 2022 · PreprintMicrobiology

ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease

G. Liu, J.-H. Lee, Z. M. Parker, D. Acharya, J. J. Chiang, M. van Gent, W. Riedl, M. E. Davis-Gardner, E. Wies, C. Chiang, M. U. Gack

This study shows ISG15 is essential for MDA5-mediated antiviral responses and is counteracted by SARS-CoV-2's PLpro protease.

bioRxiv · Oct 26, 2020Immunology