Author

T. S. Stappenbeck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

L. D. Sibley· 3 shared , J. G. Jacqueline G. Perrigoue· 1 shared A. Antia· 1 shared A. Koseki· 1 shared A. Kosugi· 1 shared B. Claggett· 1 shared B. P. Abraham· 1 shared B. Shen· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersMicrobiology

L. D. Sibley

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Author profile →

6 papers

Recent·Most cited

A high-fidelity in vitro model of the human intestinal epithelium

S. Fujii, S. T. Espenschied, V. Anand, J. Bettencourt-Silva, Y. Han, G. Ito, A. Koseki, A. Kosugi, J. Kozlowski, R. Matsumoto, S. Meng, N. Mulligan, R. J. Musich, K. Newhall, E. Ohshina, , T. S. Stappenbeck

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.

bioRxiv · Jan 1, 2024 · PreprintCell Biology

Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus.

V. Greigert, I. Saraav, J. Son, D. Dayao, A. Antia, S. Tzipori, W. Witola, T. S. Stappenbeck, S. Ding, L. D. Sibley

This study develops a human air-liquid interface culture system for Cryptosporidium hominis, revealing it induces type III interferon and reduces Rotavirus infectivity.

bioRxiv · Aug 30, 2023 · PreprintMicrobiology

HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine

M. J. Wood, J. N. Marshall, V. L. Hartley, T.-C. Liu, K. Iwai, T. S. Stappenbeck, D. A. MacDuff

This study shows HOIL1 deficiency in mice causes type 2 inflammation in the small intestine, characterized by increased ILC2 cells and cytokine expression, independent of IL4R signaling.

bioRxiv · Mar 9, 2022Immunology

Gut metabolites influence susceptibility of neonatal mice to cryptosporidiosis.

K. L. VanDussen, L. Funkhouser-Jones, M. E. Akey, D. A. Schaefer, K. Ackerman, M. W. Riggs, T. S. Stappenbeck, L. D. Sibley

This study identifies gut metabolites that influence susceptibility to Cryptosporidium infection in neonatal mice, showing that fatty acids affect parasite growth and invasion.

bioRxiv · Sep 11, 2020 · PreprintMicrobiology

Epithelial cell biomarkers are predictive of response to biologic agents in Crohn's disease

M. Osterman, K. VanDussen, I. O. Gordon, E. M. Davis, K. Li, K. Simpson, M. Ciorba, B. P. Abraham, X. Guo, E. Yee, F. Allard, , J. G. Jacqueline G. Perrigoue, B. Claggett, B. Shen, T. S. Stappenbeck, J. J. Liu

The paper shows that ileal microvillar length (MVL) predicts response to biologics ustekinumab and vedolizumab in Crohn's disease, with combined biomarkers improving prediction accuracy.

bioRxiv · May 20, 2020Cell Biology

Deficiency in Bhlhe40 impairs resistance to H. polygyrus bakeri and reveals novel Csf2rb-dependent regulation of anti-helminth immunity

N. N. Jarjour, T. R. Bradstreet, E. A. Schwarzkopf, M. E. Cook, C.-W. Lai, S. C.-C. Huang, R. Taneja, T. S. Stappenbeck, S. J. Van Dyken, J. F. Urban, B. T. Edelson

This study shows that Bhlhe40 is essential for TH2 cell immunity against H. polygyrus and reveals redundancy in βC chain-dependent cytokines.

bioRxiv · Jul 18, 2019Immunology