Author

D. B. McAffee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

J. T. Groves· 2 shared K. B. Wilhelm· 2 shared M. K. O'Dair· 2 shared S. Kim· 2 shared S. Morita· 2 shared J. J. Lin· 1 shared S. T. Low-Nam· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

J. T. Groves

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2 papers

Recent·Most cited

Discrete LAT condensates encode antigen information from single pMHC:TCR binding events

D. B. McAffee, M. K. O'Dair, J. J. Lin, S. T. Low-Nam, K. B. Wilhelm, S. Kim, S. Morita, J. T. Groves

The paper shows that LAT condensates form in response to pMHC:TCR binding events, with condensation probability linked to binding dwell time and a mutation affecting this process.

bioRxiv · Dec 16, 2021Biophysics

Height, but not binding epitope, affects the potency of synthetic TCR agonists

K. B. Wilhelm, S. Morita, D. B. McAffee, S. Kim, M. K. O'Dair, J. T. Groves

This paper investigates how the geometry of synthetic TCR agonists affects T cell activation, finding that ligand height, not epitope, determines potency.

bioRxiv · May 13, 2021Biophysics