Author

K. B. Wilhelm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 2 Assay:proteomics· 2 Assay:fluorescence / live-cell microscopy· 1 Assay:protein structure· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

J. T. Groves· 4 shared D. B. McAffee· 2 shared M. K. O'Dair· 2 shared S. Kim· 2 shared S. Morita· 2 shared A. J. Bischoff· 1 shared A. Vissa· 1 shared D. M. Garcia-Almedina· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBiophysics

J. T. Groves

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Author profile →

4 papers

Recent·Most cited

Differential Roles of Kinetic On- and Off-Rates in T-Cell Receptor Signal Integration Revealed with a Modified Fab'-DNA Ligand

K. B. Wilhelm, A. Vissa, J. T. Groves

This paper introduces a modified Fab'-DNA ligand to study TCR signal integration by controlling kinetic on- and off-rates, revealing how dwell time affects TCR signaling and LAT condensation.

bioRxiv · Apr 1, 2024Biophysics

A membrane-associated light harvesting model is enabled by functionalized assemblies of gene-doubled TMV proteins

J. Dai, K. B. Wilhelm, A. J. Bischoff, J. H. Pereira, M. T. Dedeo, D. M. Garcia-Almedina, P. D. Adams, J. T. Groves, M. B. Francis

This paper develops a synthetic light harvesting model using modified TMV proteins attached to lipid bilayers, enabling dynamic energy transfer studies.

bioRxiv · Sep 8, 2022Bioengineering

Discrete LAT condensates encode antigen information from single pMHC:TCR binding events

D. B. McAffee, M. K. O'Dair, J. J. Lin, S. T. Low-Nam, K. B. Wilhelm, S. Kim, S. Morita, J. T. Groves

The paper shows that LAT condensates form in response to pMHC:TCR binding events, with condensation probability linked to binding dwell time and a mutation affecting this process.

bioRxiv · Dec 16, 2021Biophysics

Height, but not binding epitope, affects the potency of synthetic TCR agonists

K. B. Wilhelm, S. Morita, D. B. McAffee, S. Kim, M. K. O'Dair, J. T. Groves

This paper investigates how the geometry of synthetic TCR agonists affects T cell activation, finding that ligand height, not epitope, determines potency.

bioRxiv · May 13, 2021Biophysics