Author

D. C. Briggs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Borg· 1 shared A. Cioce· 1 shared A. G. Purkiss· 1 shared A. J. Borg· 1 shared A. Nans· 1 shared A. Nawrotek· 1 shared A. Ni Cheallaigh· 1 shared B. Schumann· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. Borg

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Xylosyltransferase Bump-and-hole Engineering to Chemically Manipulate Proteoglycans in Mammalian Cells

Z. Li, L. Di Vagno, H. Chawla, A. Ni Cheallaigh, M. Critcher, D. Sammon, D. C. Briggs, N. Chung, V. Chang, K. E. Mahoney, A. Cioce, L. D. Murphy, Y.-H. Chen, Y. Narimatsu, R. L. Miller, , B. Schumann

This paper develops a chemical genetic strategy to manipulate proteoglycan glycan attachment sites in mammalian cells using modified xylosyltransferases.

bioRxiv · Dec 20, 2023 · PreprintBiochemistry

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

S. Adams, A. G. Purkiss, P. P. Knowles, A. Nans, D. C. Briggs, A. Borg, C. P. Earl, K. M. Goodman, A. Nawrotek, A. J. Borg, P. B. McIntosh, F. M. Houghton, S. Kjaer, N. Q. McDonald

The paper reports crystal and cryo-EM structures of zebrafish RET revealing conformational flexibility and strict geometric spacing in ligand-co-receptor recognition.

bioRxiv · Sep 13, 2020Biophysics