Author

D. C. Hintzen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. A. Raaijmakers· 2 shared M. Schubert· 2 shared M. Soto· 2 shared R. H. Medema· 2 shared B. Bakker· 1 shared D. C. J. Spierings· 1 shared F. Foijer· 1 shared K. Szuhai· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

J. A. Raaijmakers

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2 papers

Recent·Most cited

Reduction of chromosomal instability and inflammation is a common aspect of adaptation to aneuploidy

D. C. Hintzen, M. Schubert, M. Soto, R. H. Medema, J. A. Raaijmakers

This study shows that aneuploid cancer cells adapt by reducing chromosomal instability and inflammation, with KRAS amplification aiding this adaptation.

bioRxiv · Dec 22, 2023Cell Biology

Monosomies, trisomies and segmental aneuploidies differentially affect chromosomal stability

D. C. Hintzen, M. Soto, M. Schubert, B. Bakker, D. C. J. Spierings, K. Szuhai, P. M. Lansdorp, F. Foijer, R. H. Medema, J. A. Raaijmakers

This study investigates how different aneuploidies affect chromosomal instability in human cells, finding that trisomies increase segregation errors while monosomies do not induce CIN.

bioRxiv · Aug 31, 2021 · PreprintCell Biology