Author

P. M. Lansdorp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:DNA methylation· 2 Research Focus:development & morphogenesis· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

D. C. J. Spierings· 3 shared V. Guryev· 2 shared A. Audrey· 1 shared A. M. Heijink· 1 shared A. Ray Chaudhuri· 1 shared B. Bakker· 1 shared C. Stok· 1 shared D. C. Hintzen· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

D. C. J. Spierings

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Author profile →

3 papers

Recent·Most cited

Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors

A. M. Heijink, C. Stok, D. Porubsky, E. M. Manolika, Y. P. Kok, M. Everts, H. R. de Boer, A. Audrey, E. Wierenga, V. Guryev, D. C. J. Spierings, P. Knipscheer, A. Ray Chaudhuri, P. M. Lansdorp, M. A. T. M. van Vugt

This study shows PARP inhibitors induce sister chromatid exchanges (SCEs) through under-replicated DNA processed in mitosis, independent of homologous recombination factors.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology

Monosomies, trisomies and segmental aneuploidies differentially affect chromosomal stability

D. C. Hintzen, M. Soto, M. Schubert, B. Bakker, D. C. J. Spierings, K. Szuhai, P. M. Lansdorp, F. Foijer, R. H. Medema, J. A. Raaijmakers

This study investigates how different aneuploidies affect chromosomal instability in human cells, finding that trisomies increase segregation errors while monosomies do not induce CIN.

bioRxiv · Aug 31, 2021 · PreprintCell Biology

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

N. van Wietmarschen, S. Merzouk, N. Halsema, D. C. J. Spierings, V. Guryev, P. M. Lansdorp

This study shows that BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes, preventing genomic instability in human and murine cells.

bioRxiv · Aug 7, 2017Cell Biology