Gdnf, a germ cell-derived factor, regulates zebrafish germ cell stemness through the creation of new spermatogonial niches (germ and Sertoli cells) and inhibition of spermatogonial differentiation in an autocrine and paracrine manners
L. Doretto, A. J. Butzge, R. T. Nakajima, E. R. M. Martinez, B. Marques, M. S. Rodrigues, I. F. Rosa, J. M. B. Ricci, A. Tovo-Neto, D. Costa, G. Malafaia, C. Shao, R. H. Nobrega
This study shows Gdnf maintains zebrafish germ cell stemness by creating new niches and inhibiting differentiation through autocrine and paracrine mechanisms.
bioRxiv · Dec 25, 2021 · PreprintCell Biology