C. Shao

Phosphocitrate Is Superior to Pyrophosphate in Preventing Soft Connective Tissue Calcification in a Mouse Model of Pseudoxanthoma Elasticum

This study shows phosphocitrate is more effective than pyrophosphate in reducing calcification in PXE mice, with better oral bioavailability and fewer side effects.

High-dose oral pyrophosphate inhibits connective tissue calcification in Abcc6 null mice but affects bone structure

This study shows that only very high oral doses of pyrophosphate inhibit ectopic calcification in Abcc6-/- mice, but these doses harm bone structure and are impractical for human use.

Effect of resistant compartment on pathogen strategy in partially migratory populations

The paper examines how a resistant host compartment influences virulence evolution in migratory populations using an SIRS model, finding that longer residence in the resistant class promotes more virulent pathogens.

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver disease

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure

This study shows retinoic acid secreted by activated hepatic stellate cells promotes liver progenitor cell activation in acute liver failure, improving patient outcomes.

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

Urine proteomic characterization of active and recovered COVID-19 patients

This study characterizes urine proteomic changes in active and recovered COVID-19 patients, identifying persistent immune and metabolic alterations and potential biomarkers.

A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.

Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12

This study identifies BUD31 as a splicing factor that promotes ovarian cancer by maintaining anti-apoptotic BCL2L12 expression through exon inclusion.

ZetaSuite, A Computational Method for Analyzing Multi-dimensional High-throughput Data, Reveals Genes with Opposite Roles in Cancer Dependency

ZetaSuite analyzes multi-dimensional high-throughput data to identify genes with opposite roles in cancer dependency, revealing key genes in DNA replication/repair checkpoint.

Assessing PDB Macromolecular Crystal Structure Confidence at the Individual Amino Acid Residue Level

The paper evaluates the confidence of individual amino acid residues in PDB macromolecular crystal structures using RSCC and compares it to AlphaFold2's pLDDT scores, finding RSCC better reflects experimental reliability.

Gdnf, a germ cell-derived factor, regulates zebrafish germ cell stemness through the creation of new spermatogonial niches (germ and Sertoli cells) and inhibition of spermatogonial differentiation in an autocrine and paracrine manners

This study shows Gdnf maintains zebrafish germ cell stemness by creating new niches and inhibiting differentiation through autocrine and paracrine mechanisms.

Individual cell-based modeling of tumor cell plasticity-induced immune escape after CAR-T therapy

The paper develops a computational model to simulate tumor cell plasticity and immune escape after CAR-T therapy, finding that CAR-T stress induces tumor cells to transition into hematopoietic stem-like and myeloid-like cells, leading to relapse.

MYCN mediates cysteine addiction and sensitizes to ferroptosis

This study shows MYCN promotes cysteine addiction and ferroptosis resistance in neuroblastoma, identifying therapeutic targets for ferroptosis induction.

Contemporary clinical isolates of Staphylococcus aureus from pediatric osteomyelitis patients display unique characteristics in a mouse model of hematogenous osteomyelitis

This study uses pediatric S. aureus isolates to create musculoskeletal infections in mice, showing strain-specific differences in infection outcomes.

Chemoproteomics Maps Glycolytic Targetome in Cancer Cells

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

Rapidly cycling stem cells regenerate the intestine independent of Lgr5high cells

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

Exponential Growth of Glioblastoma In Vivo Driven by Rapidly Dividing and Outwardly Migrating Cancer Stem Cells

This study identifies that glioblastoma grows exponentially due to symmetric divisions of brain tumor stem cells (BTSCs) accumulating at the tumor rim.

Bactericidal efficiency and mechanism of specifically targeted antimicrobial peptides optimized based on structural and functional relationships

This study optimizes antimicrobial peptides to enhance their activity and specificity against E. coli by modifying structure and introducing a phage-displayed targeting moiety.

Immunogenicity and protective potency of Norovirus GII.17 virus-like particle-based vaccine

This study demonstrates that GII.17 virus-like particles (VLPs) can be produced and show protective potency against NoV GII.17 infection by blocking saliva histo-blood group antigen binding.

Continuous Evaluation of Ligand Protein Predictions: A Weekly Community Challenge for Drug Docking

CELPP evaluates docking workflows by challenging participants to predict new protein-ligand structures weekly, assessing accuracy to identify strengths and weaknesses in drug docking methods.