Author

D. D. Engle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. D. Riggs· 1 shared A. Ianniciello· 1 shared A. Limpert· 1 shared D. A. Tirrell· 1 shared F. Esni· 1 shared H. Ren· 1 shared H. T. Ku· 1 shared H. Tiriac· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. D. Riggs

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of a distinct ductal subpopulation with self-renewal and differentiation potential from the adult murine pancreas

J. R. Tremblay, J. A. Ortiz, J. C. Quijano, H. Zook, J. M. LeBon, W. Li, K. Jou, W. Tsark, J. R. Mann, M. Kozlowski, D. A. Tirrell, F. Esni, D. D. Engle, A. D. Riggs, H. T. Ku

The paper identifies a rare ductal cell subpopulation in adult mice with progenitor-like properties that contribute to pancreas regeneration and tumor progression.

Stem Cells · Apr 15, 2024Peer-reviewedCell Biology

The impact of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids

J. C. Lumibao, S. R. Okhovat, K. Peck, X. Lin, K. Lande, J. Zou, D. D. Engle

This study evaluates how different extracellular matrix sources affect drug response and gene expression in pancreatic cancer organoids, finding no significant impact on pharmacotyping results.

bioRxiv · Jan 26, 2023Cancer Biology

The autophagy initiating kinase ULK1 is required for pancreatic cancer cell growth and survival

R. J. Shaw, S. N. Brun, J. Lumibao, A. Limpert, H. Ren, A. Ianniciello, N. Cosford, H. Tiriac, M. Downes, R. Evans, D. D. Engle

This study shows ULK1 is essential for pancreatic cancer cell growth and survival, and ULK1 inhibitors can enhance immunotherapy by increasing MHC Class I expression.

bioRxiv · May 15, 2021 · PreprintCancer Biology