Author

H. Tiriac

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:wet-lab / biochemical assay· 2

Frequent Co-Authors

M. Downes· 2 shared A. D. Borowsky· 1 shared A. F. Pinto· 1 shared A. Ianniciello· 1 shared A. Kolarzyk· 1 shared A. Lazenby· 1 shared A. Limpert· 1 shared A. M. Lowy· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCancer Biology

M. Downes

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression

G. Liang, T. G. Oh, N. Hah, H. Tiriac, Y. Shi, M. L. Truitt, C. E. Antal, A. R. Atkins, Y. Li, C. Fraser, S. Ng, A. F. Pinto, D. C. Nelson, S. Bashi, E. Banayo, , R. M. Evans

This study shows that inhibiting stromal Class I HDACs reduces pancreatic cancer progression by targeting desmoplastic and pro-tumorigenic programs in cancer-associated fibroblasts.

Nature Communications · Dec 6, 2023Peer-reviewedCancer Biology

Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma

M. V. Recouvreux, C. M. Galapate, S. Grenier, E. Esparza, Y. Zhang, S. Maganti, R. Naeem, D. A. Scott, A. M. Lowy, H. Tiriac, C. Commisso

This study shows that DON inhibits PDAC growth by targeting asparagine metabolism, and combining DON with ASNase reduces metastasis.

Nature Cancer · Oct 9, 2023Peer-reviewedCancer Biology

Engrailed-1 Promotes Pancreatic Cancer Metastasis

J. Xu, J. S. Roe, E. Lee, C. Tonelli, T. Somerville, M. Yao, J. Milazzo, H. Tiriac, A. Kolarzyk, E. Lee, J. Grem, A. Lazenby, J. Grunkemeyer, M. Hollingsworth, A. D. Borowsky, , C.-i. Hwang

This study shows EN1 promotes pancreatic cancer metastasis by repressing target genes and enhancing mesenchymal properties.

bioRxiv · Apr 10, 2023 · PreprintCancer Biology

Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model.

J. S. S. Narayanan, T. Hayashi, S. Erdem, S. McArdle, H. Tiriac, P. Ray, M. Pu, Z. Mikulski, A. Miller, K. Messer, D. Carson, S. P. Schoenberger, R. R. White

bioRxiv · Oct 4, 2022Cancer Biology

The autophagy initiating kinase ULK1 is required for pancreatic cancer cell growth and survival

R. J. Shaw, S. N. Brun, J. Lumibao, A. Limpert, H. Ren, A. Ianniciello, N. Cosford, H. Tiriac, M. Downes, R. Evans, D. D. Engle

This study shows ULK1 is essential for pancreatic cancer cell growth and survival, and ULK1 inhibitors can enhance immunotherapy by increasing MHC Class I expression.

bioRxiv · May 15, 2021 · PreprintCancer Biology