Author

J. R. Mann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

C. J. Donnelly· 2 shared A. C. Murthy· 1 shared A. Chesi· 1 shared A. D. Riggs· 1 shared A. M. Gleixner· 1 shared A. R. Rodan· 1 shared A. R. Subramanya· 1 shared A. Smirnov· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

C. J. Donnelly

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of a distinct ductal subpopulation with self-renewal and differentiation potential from the adult murine pancreas

J. R. Tremblay, J. A. Ortiz, J. C. Quijano, H. Zook, J. M. LeBon, W. Li, K. Jou, W. Tsark, J. R. Mann, M. Kozlowski, D. A. Tirrell, F. Esni, D. D. Engle, A. D. Riggs, H. T. Ku

The paper identifies a rare ductal cell subpopulation in adult mice with progenitor-like properties that contribute to pancreas regeneration and tumor progression.

Stem Cells · Apr 15, 2024Peer-reviewedCell Biology

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

L. Guo, J. R. Mann, J. C. Mauna, K. E. Copley, H. Wang, J. D. Rubien, H. M. Odeh, J. Lin, B. L. Lee, L. Ganser, E. Robinson, K. M. Kim, A. C. Murthy, T. Paul, B. Portz, , J. Shorter

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

bioRxiv · Sep 4, 2023Biochemistry

WNK kinases sense molecular crowding and rescue cell volume via phase separation

C. R. Boyd-Shiwarski, D. J. Shiwarski, S. E. Griffiths, R. T. Beacham, L. Norrell, D. E. Morrison, J. Wang, J. R. Mann, W. Tennant, E. N. Anderson, J. Franks, M. Calderon, K. A. Connolly, C. J. Weaver, C. C. Weckerly, , A. R. Subramanya

This study shows WNK1 senses molecular crowding by phase separation to activate volume recovery in hypertonic conditions through phosphorylation-dependent signaling.

bioRxiv · Jan 10, 2022Cell Biology