Stimulating the sir2-pgc-1α axis rescues exercise capacity and mitochondrial respiration in Drosophila tafazzin mutants.
D. Damschroder, R. Zapata-Perez, R. H. Houtkooper, R. Wessells
The paper shows that nicotinamide riboside rescues exercise capacity and mitochondrial respiration in Drosophila tafazzin mutants via the Sir2/Pgc-1α pathway.
bioRxiv · Jan 6, 2022 · PreprintPhysiology