Author

R. H. Houtkooper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:metabolism & bioenergetics· 4 Research Focus:cell type annotation· 3 Assay:metabolomics· 3 Assay:bulk RNA-seq· 2 Organism:C. elegans· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

G. E. Janssens· 4 shared F. M. Vaz· 3 shared A. W. Gao· 2 shared H. L. Elfrink· 2 shared M. van Weeghel· 2 shared R. L. Smith· 2 shared A. C. Luyf· 1 shared A. E. Green· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersCell Biology

G. E. Janssens

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Author profile →

5 papers

Recent·Most cited

Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

K. Reid, E. G. Daniels, G. Vasam, R. Kamble, G. E. Janssens, M. Hu, A. E. Green, R. H. Houtkooper, K. J. Menzies

This study shows that reducing Mrpl54 expression in mice decreases mitochondrial-encoded protein content but does not improve metabolic health or lifespan.

bioRxiv · Nov 5, 2022 · PreprintCell Biology

Stimulating the sir2-pgc-1α axis rescues exercise capacity and mitochondrial respiration in Drosophila tafazzin mutants.

D. Damschroder, R. Zapata-Perez, R. H. Houtkooper, R. Wessells

The paper shows that nicotinamide riboside rescues exercise capacity and mitochondrial respiration in Drosophila tafazzin mutants via the Sir2/Pgc-1α pathway.

bioRxiv · Jan 6, 2022 · PreprintPhysiology

Reduced ech-6 Expression Attenuates Fat-induced Premature Aging in C. elegans

Y. J. Liu, A. W. Gao, R. L. Smith, G. E. Janssens, D. M. Panneman, A. Jongejan, M. van Weeghel, F. M. Vaz, M. J. Silvestrini, L. R. Lapierre, A. W. MacInnes, R. H. Houtkooper

This study shows that reducing ech-6 expression in C. elegans mitigates fat-induced premature aging, suggesting a role for ech-6 in metabolic flexibility and longevity.

bioRxiv · Nov 2, 2020 · PreprintCell Biology

Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

N. M. Held, R. Buijink, H. L. Elfrink, S. Kooijman, G. E. Janssens, F. M. Vaz, S. Michel, R. H. Houtkooper, M. Weeghel van

This study shows aging reduces lipid oscillations in adipose tissues, with BAT showing specific acyl chain length-dependent rhythms lost in older mice.

bioRxiv · Sep 4, 2020Biochemistry

Metabolomics and lipidomics in C. elegans using a single sample preparation

M. Molenaars, B. V. Schomakers, H. L. Elfrink, A. W. Gao, M. A. T. Vervaart, M. L. Pras-Raves, A. C. Luyf, R. L. Smith, M. G. Sterken, J. E. Kammenga, A. H. C. van Kampen, G. E. Janssens, F. M. Vaz, M. van Weeghel, R. H. Houtkooper

This paper introduces a single-sample preparation method for comprehensive metabolomics and lipidomics in C. elegans, enabling semi-quantitative analysis of over 100 polar metabolites and over 1000 apolar metabolites.

bioRxiv · Jul 6, 2020Biochemistry