The MNK1/2-eIF4E axis contributes to phenotype switching, melanoma progression, and resistance to immunotherapy.
F. Huang, C. Goncalves, M. Bartish, J. Remy-Sarrazin, Q. Guo, A. Emond, W. Yang, D. Plourde, J. Su, M. G. Gimeno, Y. Zhan, M. Attias, A. Galan, T. rzymski, M. Mazan, , S. del Rincon
This study identifies the MNK1/2-eIF4E axis as a driver of melanoma phenotype switching, progression, and immunotherapy resistance, with potential therapeutic targeting.
bioRxiv · May 29, 2020Cancer Biology