Author

S. S. Ng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:development & morphogenesis· 2 Assay:imaging· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Kumar· 1 shared A. M. Richards· 1 shared A. M. Syanda· 1 shared A. S. NG· 1 shared A. WEE· 1 shared B. G. M. Hughes· 1 shared B. MICKELSON· 1 shared C. A. Scott· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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1 shared paperImmunology

A. Kumar

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Author profile →

6 papers

Recent·Most cited

Type I interferon drives a cellular state inert to TCR-stimulation and could impede effective T-cell differentiation in cancer

D. Corvino, M. Batstone, B. G. M. Hughes, T. Kempchen, S. S. Ng, N. Salim, F. Schneppenheim, D. Rommel, A. Kumar, S. Pearson, J. Madore, L. T. Koufariotis, L. M. Steinheuer, D. Pathirana, K. Thurley, , T. Bald

The paper identifies a subset of CD8+ TILs in HPV-HNSCC enriched for interferon-stimulated genes that are transcriptionally inert to TCR stimulation and may hinder T-cell differentiation.

bioRxiv · Mar 28, 2024Immunology

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signalingduring steatohepatitis in diet-induced NAFLD.

Z. S. LOW, D. CHUA, H. S. CHENG, R. TEE, W. R. TAN, C. BALL, N. B. E. SAHIB, S. S. NG, J. QU, Y. LIU, H. HONG, C. CAI, N. C. L. RAO, A. WEE, M. D. MUTHIAH, , W. WAHLI

The paper identifies Angptl4's role in shaping intrahepatic T-cell activation via eIF2α signaling during fibrosis in diet-induced NAFLD.

bioRxiv · Jan 10, 2023 · PreprintImmunology

Small molecule screen employing patient-derived iPS hepatocytes identifies LRRK2 as a novel therapeutic target for Alpha1 Antitrypsin Deficiency

D. Kent, S. S. Ng, P. Khoshkenar, A. M. Syanda, L. Chao Zheng, M. Zieger, C. Greer, S. B. Hatch, J. M. Segal, S. J. I. Blackford, V. Chowdary, T. Ismali, D. Danovi, S. Sahdeo, D. Ebner, , S. T. Rashid

A small molecule screen in patient iPSCs with in vivo validation in mice identifies LRRK2 as a new therapeutic target for Alpha-1 Antitrypsin Deficiency.

bioRxiv · Sep 17, 2021 · PreprintCell Biology

Matriptase generates a tissue damage response via promoting Gq signalling, leading to RSK and DUOX activation

J. Ma, C. A. Scott, Y. N. Ho, K. S. Marsay, C. Zhang, C. K. J. Teow, S. S. Ng, W. Zhang, V. Tergaonkar, L. J. Partridge, S. Roy, E. Amaya, T. J. Carney

This study shows that Matriptase promotes tissue damage responses by activating Gq signaling, leading to RSK and DUOX activation, which disrupts epithelial junctions and contributes to inflammation and carcinoma.

bioRxiv · Jan 21, 2021 · PreprintCell Biology

Increased isoDGR motifs in plasma fibronectin are associated with atherosclerosis through facilitation of vascular fibrosis

J. E. Park, X. Guo, K. C. K. Liou, S. E. Lynn, S. S. Ng, W. Meng, S. C. Lim, M. K.-S. Leow, A. M. Richards, D. J. Pennington, N. E. McCarthy, D. P. V. de Kleijn, V. Sorokin, H. H. Ho, S. K. Sze

This study shows that deamidated fibronectin with isoDGR motifs promotes vascular fibrosis and atherosclerosis by enhancing integrin signaling and leukocyte recruitment.

bioRxiv · Jul 21, 2020 · PreprintBiochemistry

Autonomous induction of hepatic polarity to construct single cell liver

Y. Zhang, R. de Mets, C. Monzel, P. Toh, N. Van Hul, S. S. Ng, T. Rashid, V. Viasnoff

This study shows that mature hepatocytes can autonomously polarize to form secretory hemi-apical lumens on bio-functionalized substrates, enabling controlled study of lumenogenesis.

bioRxiv · May 15, 2019 · PreprintCell Biology