Author

D. De Vecchis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. C. Kalli· 3 shared D. J. Beech· 3 shared A. J. Hyman· 2 shared J. Chong· 2 shared J. Shi· 2 shared A. Negre-Salvayre· 1 shared B. H. Justesen· 1 shared L. C. Paweletz· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

A. C. Kalli

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Coupling the role of lipids to the conformational dynamics of the ABC transporter P-gp

D. De Vecchis, L. Schäfer

This study uses molecular dynamics simulations to show how lipid environment and ATP affect the conformational dynamics and substrate cavity accessibility of P-gp conformers.

bioRxiv · Apr 18, 2024Biophysics

Anionic phospholipids stimulate the proton pumping activity of the plant plasma membrane P-type H+-ATPase

L. C. Paweletz, S. L. Holtbrügge, M. Löb, D. De Vecchis, L. V. Schäfer, T. Günther Pomorski, B. H. Justesen

This study shows that anionic phospholipids, particularly phosphatidylserine, enhance the proton pumping activity of the plant plasma membrane H+-ATPase AHA2.

bioRxiv · May 12, 2023Biochemistry

Molecular principles of Piezo1 activation by increased membrane tension

D. De Vecchis, D. J. Beech, A. C. Kalli

This study reveals the structural changes in Piezo1 during mechanical activation, showing how membrane tension induces conformational changes leading to channel opening.

bioRxiv · Sep 6, 2020Biophysics

Sphingomyelinase disables Piezo1 channel inactivation to enable sustained response to mechanical force

J. Shi, A. J. Hyman, D. De Vecchis, J. Chong, L. Lichtenstein, S. T. Futers, M. Rouahi, A. Negre-Salvayre, N. Auge, A. C. Kalli, D. J. Beech

The paper shows sphingomyelinase disables Piezo1 channel inactivation, allowing sustained mechanical force response in vascular endothelial cells.

bioRxiv · Oct 4, 2019Physiology

Computational reconstruction of the complete Piezo1 structure reveals a unique footprint and specific lipid interactions

J. Chong, D. De Vecchis, A. J. Hyman, O. V. Povstyan, J. Shi, D. J. Beech, A. C. Kalli

This study computationally reconstructs the full-length Piezo1 structure, revealing its trilobed topology, lipid interactions, and how membrane stiffness affects its shape.

bioRxiv · Sep 26, 2019Biophysics