Author

L. Lichtenstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1

Frequent Co-Authors

D. J. Beech· 3 shared G. Parsonage· 2 shared S. Futers· 2 shared A. C. Kalli· 1 shared A. J. Hyman· 1 shared A. Negre-Salvayre· 1 shared C. Konstantinou· 1 shared C. W. Cheng· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersPhysiology

D. J. Beech

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PIEZO1 force sensing controls global lipid homeostasis

L. Lichtenstein, C. W. Cheng, E. L. Evans, H. J. Gaunt, F. Bartoli, E. Chuntharpursat-Bon, S. Patel, C. Konstantinou, S. Futers, M. Reay, G. Parsonage, J. Bertrand-Michel, P. Sukumar, L. D. Roberts, D. J. Beech

This study shows that endothelial PIEZO1 force sensing regulates lipid homeostasis by affecting cholesterol metabolism and excretion, with implications for hyperlipidaemia.

bioRxiv · Jul 23, 2023 · PreprintPhysiology

Sphingomyelinase disables Piezo1 channel inactivation to enable sustained response to mechanical force

J. Shi, A. J. Hyman, D. De Vecchis, J. Chong, L. Lichtenstein, S. T. Futers, M. Rouahi, A. Negre-Salvayre, N. Auge, A. C. Kalli, D. J. Beech

The paper shows sphingomyelinase disables Piezo1 channel inactivation, allowing sustained mechanical force response in vascular endothelial cells.

bioRxiv · Oct 4, 2019Physiology

Piezo1 channel activates ADAM10 sheddase to regulate Notch1 and gene expression

D. J. Beech, V. Caolo, M. Debant, N. Endesh, S. Futers, L. Lichtenstein, G. Parsonage, E. A. V. Jones

The paper shows that Piezo1 channels activate ADAM10 to regulate Notch1 cleavage and gene expression in response to mechanical force.

bioRxiv · Aug 12, 2019 · PreprintCell Biology