Author

J. Chong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. C. Kalli· 2 shared A. J. Hyman· 2 shared D. De Vecchis· 2 shared D. J. Beech· 2 shared J. Shi· 2 shared A. BriegeliD· 1 shared A. E. Leschziner· 1 shared A. Fung· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersPhysiology

A. C. Kalli

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Elf1 promotes Rad26 interaction with lesion-arrested Pol II for transcription-coupled repair

R. Sarsam, J. Xu, I. Lahiri, W. Gong, J. Oh, Z. Zhou, J. Chong, N. Hao, S. Li, D. Wang, A. E. Leschziner

The paper investigates how Rad26 interacts with lesion-arrested Pol II and identifies Elf1's role in enhancing this interaction for transcription-coupled repair.

bioRxiv · Sep 8, 2023Biophysics

A high throughput bispecific antibody discovery pipeline

A. I. Segaliny, J. Jayaraman, X. Chen, J. Chong, R. Luxon, A. Fung, Q. Fu, X. Jiang, R. Rivera, X. Ma, C. Ren, J. Zimak, P. N. Hedde, Y. Shang, G. Wu, W. Zhao

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

bioRxiv · Sep 7, 2021Bioengineering

SARS-CoV-2 lineage B.6 is the major contributor to transmission in Malaysia

Y. M. Chong, I.-C. Sam, J. Chong, M. Kahar Bador, S. Ponnampalavanar, S. F. Syed Omar, A. Kamarulzaman, V. Munusamy, C. K. Wong, F. H. Jamaluddin, Y. F. Chan

This study analyzes SARS-CoV-2 genome sequences from Malaysia to show that lineage B.6 became the dominant cause of community transmission following a religious mass gathering, with global implications.

PLOS Neglected Tropical Diseases · Nov 30, 2020Peer-reviewedMicrobiology

Engineered chemotaxis core signaling units indicate a constrained kinase-off state

A. Muok, T. Khiang Chua, M. Srivastava, W. Yang, Z. Maschmann, P. P. Borbat, J. Chong, S. Zhang, J. H. Freed, A. Briegel, B. R. Crane

The paper investigates how engineered chemoreceptor complexes stabilize a kinase-off state by sequestering kinase and substrate domains, using multiple biophysical techniques.

Science Signaling · Nov 10, 2020Peer-reviewedBiochemistry

Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size

I. Kondrychyn, D. J. Kelly, N. Taberner, A. Nomori, K. Kato, J. Chong, H. Nakajima, S. Okuda, N. Mochizuki, L.-K. Phng

This study shows that Marcksl1 modulates endothelial cell mechanical responses to blood flow, affecting vessel size and shape during angiogenesis.

bioRxiv · Aug 6, 2020Cell Biology

Sphingomyelinase disables Piezo1 channel inactivation to enable sustained response to mechanical force

J. Shi, A. J. Hyman, D. De Vecchis, J. Chong, L. Lichtenstein, S. T. Futers, M. Rouahi, A. Negre-Salvayre, N. Auge, A. C. Kalli, D. J. Beech

The paper shows sphingomyelinase disables Piezo1 channel inactivation, allowing sustained mechanical force response in vascular endothelial cells.

bioRxiv · Oct 4, 2019Physiology

Computational reconstruction of the complete Piezo1 structure reveals a unique footprint and specific lipid interactions

J. Chong, D. De Vecchis, A. J. Hyman, O. V. Povstyan, J. Shi, D. J. Beech, A. C. Kalli

This study computationally reconstructs the full-length Piezo1 structure, revealing its trilobed topology, lipid interactions, and how membrane stiffness affects its shape.

bioRxiv · Sep 26, 2019Biophysics

Functional characterization of fatty acyl desaturase Fads2 and Elovl5 elongase in the Boddart’s goggle-eyed goby, Boleophthalmus boddarti (Gobiidae) suggest an incapacity for long-chain polyunsaturated fatty acid biosynthesis

H.-J. Soo, J. Chong, N.-S. Lau, S.-Y. Ting, K.-K. Sam, M.-K. Kuah, Y. K. Sim, M. Janaranjani, A. S. C. Chong

This study characterizes Fads2 and Elovl5 in Boleophthalmus boddarti, showing they cannot biosynthesize long-chain polyunsaturated fatty acids, relying on diet.

bioRxiv · Aug 29, 2019Zoology