D. J. Beech

Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells

This paper identifies a small molecule that reduces IR:IGF-1R hybrid formation in human endothelial cells, increasing Akt phosphorylation and altering PI3-kinase signaling.

Pico145 inhibits TRPC4-mediated mICAT and postprandial small intestinal motility

This study shows that Pico145 inhibits TRPC4-mediated mICAT and reduces postprandial intestinal motility in mice.

PIEZO1 force sensing controls global lipid homeostasis

This study shows that endothelial PIEZO1 force sensing regulates lipid homeostasis by affecting cholesterol metabolism and excretion, with implications for hyperlipidaemia.

Low oscillatory shear stress regulates Weibel-Palade body size and vWF release.

The paper shows that low oscillatory shear stress increases Weibel-Palade body size, enhancing vWF release and thrombotic potential in endothelial cells.

A small molecule reveals role of insulin receptor-insulin like growth factor-1 receptor heterodimers

The paper identifies a small molecule that inhibits insulin receptor-insulin-like growth factor-1 receptor heterodimers, revealing their distinct physiological role in endothelial cells.

Paracrine role for endothelial IGF-1 receptor in white adipocyte beiging

This study shows that reducing endothelial IGF-1R in nutrient excess promotes white adipocyte beiging, increases energy expenditure, and improves insulin sensitivity through paracrine malonic acid release.

Suppression of aminoglycoside-induced premature termination codon readthrough by the TRP channel inhibitor AC1903

This study shows that AC1903 suppresses aminoglycoside-induced PTC readthrough by inhibiting multiple TRPC channels, but its mechanism remains unclear.

Molecular principles of Piezo1 activation by increased membrane tension

This study reveals the structural changes in Piezo1 during mechanical activation, showing how membrane tension induces conformational changes leading to channel opening.

Sphingomyelinase disables Piezo1 channel inactivation to enable sustained response to mechanical force

The paper shows sphingomyelinase disables Piezo1 channel inactivation, allowing sustained mechanical force response in vascular endothelial cells.

Computational reconstruction of the complete Piezo1 structure reveals a unique footprint and specific lipid interactions

This study computationally reconstructs the full-length Piezo1 structure, revealing its trilobed topology, lipid interactions, and how membrane stiffness affects its shape.

Piezo1 channel activates ADAM10 sheddase to regulate Notch1 and gene expression

The paper shows that Piezo1 channels activate ADAM10 to regulate Notch1 cleavage and gene expression in response to mechanical force.

Stimulation of cardiac fibroblast Piezo1 channels opposes myofibroblast differentiation and induces IL-6 secretion via Ca2+-mediated p38 MAP kinase activation

This study shows that activating Piezo1 channels in cardiac fibroblasts reduces myofibroblast differentiation and increases IL-6 secretion through Ca2+-dependent p38 MAP kinase activation.

Cell adhesion molecule interaction with Piezo1 channels is a mechanism for sub cellular regulation of mechanical sensitivity

The paper investigates the interaction between Piezo1 channels and cell adhesion molecules, showing how this interaction modulates mechanical sensitivity at the subcellular level.

Piezo1 channel agonist mimics high glucose as a stimulator of insulin release

This study shows that Piezo1 agonist Yoda1 stimulates insulin release from beta-cells and pancreatic islets, suggesting Piezo1's role in cell swelling-induced insulin secretion.