Author

A. J. Hyman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. C. Kalli· 2 shared D. De Vecchis· 2 shared D. J. Beech· 2 shared J. Chong· 2 shared J. Shi· 2 shared A. Negre-Salvayre· 1 shared L. Lichtenstein· 1 shared M. Rouahi· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPhysiology

A. C. Kalli

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Author profile →

2 papers

Recent·Most cited

Sphingomyelinase disables Piezo1 channel inactivation to enable sustained response to mechanical force

J. Shi, A. J. Hyman, D. De Vecchis, J. Chong, L. Lichtenstein, S. T. Futers, M. Rouahi, A. Negre-Salvayre, N. Auge, A. C. Kalli, D. J. Beech

The paper shows sphingomyelinase disables Piezo1 channel inactivation, allowing sustained mechanical force response in vascular endothelial cells.

bioRxiv · Oct 4, 2019Physiology

Computational reconstruction of the complete Piezo1 structure reveals a unique footprint and specific lipid interactions

J. Chong, D. De Vecchis, A. J. Hyman, O. V. Povstyan, J. Shi, D. J. Beech, A. C. Kalli

This study computationally reconstructs the full-length Piezo1 structure, revealing its trilobed topology, lipid interactions, and how membrane stiffness affects its shape.

bioRxiv · Sep 26, 2019Biophysics