H. Gao

Synergistic Multi-Enzyme Cascades Assembled on Modular Protein Scaffolds for Efficient PET Biorecycling

This paper develops a modular protein scaffold system to assemble multiple enzymes for efficient PET biorecycling, achieving higher conversion rates than previous systems.

MDF regulates a network of auxin-dependent and -independent pathways of adventitious root regeneration in Arabidopsis.

The paper identifies MDF as a regulator that coordinates auxin-dependent and -independent pathways in adventitious root regeneration in Arabidopsis.

Terrestrial ecosystems enhance root zones in response to intensified drought

The paper quantifies a 11% global increase in root zone water storage capacity from 1982-2020, highlighting its impact on hydrological and ecological processes under climate change.

Genotypic-phenotypic landscape computation based on first principle and deep learning

The paper develops a deep learning framework to map genotypes to fitness, applies it to predict viral mutations and immune escape, and computes the genotype-fitness landscape for SARS-CoV-2.

Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

This study shows that microbiota from young mice reduces age-related gout susceptibility by increasing butyric acid and modulating uric acid metabolism in aged mice.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

Human Amniotic Epithelial Cells Promote Chx10-/Pax6+ Muller Glia Subpopulation Reprogramming into Photoreceptor-like Cells

This study identifies a specific Muller glia subpopulation that can be reprogrammed into photoreceptor-like cells through transplantation of human amniotic epithelial cells.

Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.

Identification of a distinct cluster of GDF15high macrophages exhibiting anti-inflammatory activities

The paper identifies a distinct cluster of GDF15high macrophages with anti-inflammatory properties using single-cell RNA sequencing and functional assays.

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

Exploration of the intricacies of low light-induced changes in cigar tobacco leaf anticlinal growth: A holistic approach from anatomical and hormonal levels to gene expression

This study examines how low light affects cigar tobacco leaf morphology, growth rates, and gene expression, revealing hormonal and cellular changes in leaf structure.

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

Single nuclei chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry

The paper develops a chromatin accessibility and gene expression atlas of human breast tissues from 92 donors of diverse genetic ancestry, identifying 10 cell types and ancestry-dependent gene expression patterns.

BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CAH1047R oncogene.

This paper compares single-cell transcriptomes of BRCA1/2 mutation carriers and non-carriers to show how these mutations alter signaling pathways and drive breast cancer development through PIK3CA mutations.

Harnessing Gradients for Self-Assembly of Peptide-Based Nanocapsules: A Pathway to Advanced Drug Delivery Systems

The paper describes the spontaneous formation of peptide-based nanocapsules through a solvent gradient-driven self-assembly process, offering a new approach for drug delivery systems.

Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2

This study shows that inhibiting HOTAIR and EZH2 reduces ovarian cancer stem cell resistance to platinum chemotherapy and improves survival in vivo.

Focusing antibody responses to the fusion peptide in rhesusmacaques

This study uses continuous immunogen delivery in rhesus macaques to focus antibody responses on the HIV fusion peptide, identifying key residues for vaccine design.

A novel bacterial signal transduction system specifically senses and responds to peptidoglycan damage

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

A hierarchical strategy to decipher protein dynamics in vivo with chemical cross-linking mass spectrometry

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

Cyclic di-GMP interact with putrescine via a PilZ domain receptor YcgR

This study shows that c-di-GMP interacts with putrescine via the YcgR receptor to regulate bacterial motility in Dickeya oryzea, with c-di-GMP inhibiting putrescine's effect.

Antibody-mediated cell entry of SARS-CoV-2

This study shows that certain monoclonal antibodies can replace ACE2 to mediate SARS-CoV-2 entry into cells, indicating that ACE2 is not essential for viral infection.

Protective effect of plasma neutralization from prior SARS-CoV-2 Omicron infection against BA.5 subvariant symptomatic reinfection

The paper assesses the protective effect of neutralizing antibodies from prior Omicron BA.5 infection against symptomatic reinfection with BA.5, BF.7, CH.1.1, and XBB.1.5 subvariants, finding a strong correlation between antibody titers and reduced reinfection risk.

Vaccinia virus induces EMT-like transformation and RhoA-mediated mesenchymal migration

This study shows vaccinia virus induces EMT-like changes and RhoA-mediated mesenchymal migration in epithelial cells, facilitating viral spread.

USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

CONSTANS alters the circadian clock in Arabidopsis thaliana

This study identifies a feedback loop between the photoperiod pathway and the circadian clock in Arabidopsis thaliana, showing that CONSTANS (CO) regulates key circadian genes.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

STING-dependent cytosolic DNA sensing pathway drives the progression to leukemia in TET2-mutated HSPCs

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.